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Oseltamivir phosphate

Oseltamivir phosphate CAS NO.204255-11-8

  • FOB Price: USD: 50.00-100.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram,Other
  • Available Specifications:

    一(1-100)Kilogram一(100-1000)Kilogram

  • Product Details

Keywords

  • Oseltamivir phosphate
  • NTERMEDIATES OF OSELTAMIVIR
  • Ro 64-0796/002

Quick Details

  • ProName: Oseltamivir phosphate
  • CasNo: 204255-11-8
  • Molecular Formula: C16H31N2O8P
  • Appearance: White powder
  • Application: Ribociclib succinate (LEE011 succinate...
  • DeliveryTime: 3-7days
  • PackAge: fiber can
  • Port: Tianjin Xingang/Qingdao Port
  • ProductionCapacity: 100 Metric Ton/Month
  • Purity: 98%
  • Storage: Seal and store in a cool and dry place
  • Transportation: By sea/air/land
  • LimitNum: 1 Kilogram

Superiority

1. Product advantages
High purity, all above 98.5%, no impurities after dissolution
We will test each batch to ensure quality
OEM and private brand services designed for free
Various cap colors available
We can also provide MT1 peptide powder
2. Factory advantages
Professional research team
More than 5 doctors in high-tech R&D laboratories
More than 1000 m2 of factory production line to ensure stable supply
More than 1200 factories to manufacture products and control quality
3. Service advantages
24-hour online service
Track package information and update it for customers
Professional sales team
Accept small order service
Redelivery service if detained by customs

Details

Oseltamivir photosphate (GS 4104) is a neuraminidase inhibitor used for the prevention and treatment of influenza (influenza A and B).
Related categories
Signal Pathways>>Anti Infection>>Influenza Virus
Research Fields>>Infection
Target point
Influenza A and B [1]
In vitro study of oseltamivir phosphate (OP) is a prodrug that is easily absorbed from the gastrointestinal tract after oral administration, and is mainly converted into osemivir carboxylate (OC) through liver esterase [1]. Oseltamivir photosphate is a widely used anti influenza sialidase inhibitor. Using one-way ANOVA testicles, using 305 μ M osemivir phosphate treatment (p=0.005 and p<0.0001) significantly reduced the metabolic activity of CMA07 and CMT-U27 cell lines. Compared to the control cells, at 0.305 μ M (p=0.9781), 3.05 μ M (p=0.7436) and 30.5 μ No statistically significant changes were observed in the treatment of M (p=0.9623) with osemivir phosphate. Finally, in order to evaluate the effect of osemivir phosphate on programmed cell death in CMA07 and CMT-U27, and considering 305 μ M osemivir phosphate treatment impairs cellular metabolic activity and uses TUNEL assay for programmed cell death measurement. 24 hour oseltamivir phosphate treatment, especially 305 μ M. Significantly increased DNA fragmentation in CMA07 (p=0.001) and CMT-U27 (p=0.0002), indicating a promotion of programmed cell death compared to lower concentrations of osemivir or PBS [2].
Mice treated with oseltamivir phosphate in vivo showed significantly more inflammatory infiltration in primary tumors (p=0.01). Ki-67 antigen and caspase-3 protein were used to evaluate the proliferation and apoptosis of CMT-U27 xenograft tumor cells, respectively. In fact, there was no difference in the expression of Ki-67 and caspase-3 (p=0.2) between mice treated with osemivir and untreated mice [2].
For each condition, CMA07 and CMT-U27 cells were cultured in triplicate on a 24 well plate: 0.305 μ M. 3.05 μ M. 30.5 μ M and 305 μ M phosphate oseltamivir and PBS were used as controls. Cells were counted daily in the Neubauer room at a dilution of 0.4% trypan blue 1:2 for 7 days, and a volume conversion factor of 1mm 3 was used (1 × 104) Perform cell counting. This measurement is repeated 3 times and the growth curve is tracked [2].
Animal experimental mice [2] Female NIH (S) II nu/nu nude mice, 4-6 weeks old, using needle 25 in a breast fat pad × 106 live CMT-U27 dog

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