1. Product advantages
High purity, all above 98.5%, no impurities after dissolution
We will test each batch to ensure quality
OEM and private brand services designed for free
Various cap colors available
We can also provide MT1 peptide powder
2. Factory advantages
Professional research team
More than 5 doctors in high-tech R&D laboratories
More than 1000 m2 of factory production line to ensure stable supply
More than 1200 factories to manufacture products and control quality
3. Service advantages
24-hour online service
Track package information and update it for customers
Professional sales team
Accept small order service
Redelivery service if detained by customs

Product Introduction:、

Description (-) - (S) - Equol is an estrogen receptor β  Estrogen receiver β)  High affinity ligand for.
Related categories
Signal Pathways>>Other>>Estrogen Receptors/ERR
Research Fields>>Cancer
Research Fields>>Metabolic Diseases
Research Fields>>Neurological Diseases
Natural Products>>Phenols
Target point
Human Endogenic Metabolite
In Vitro Studies (-) - (S) - Equol Display for ER β The maximum affinity (Ki=0.73 ± 0.2 nM) for ER α The affinity (Ki=6.41 ± 1 nM) is relatively poor [1]. (-) - (S) - Equol inhibits the growth of LNCaP, DU145, and PC3 human prostate cancer cell lines. (-) - (S) - Equol induces cell apoptosis by downregulating cyclin B1 and CDK1, upregulating CDK inhibitors (p21 and p27), and upregulating Fas ligand (FasL), leading to cell cycle arrest in the G2/M phase of PC3 cells And the expression of proapoptotic Bim. (-) - (S) - Equol increases the expression of FOXO3a, decreases the expression of p-FOXO3a, and enhances the nuclear stability of FOXO3a. (-) - (S) - Equol also reduces the expression of MDM2, which acts as the E3 ubiquitin ligase of p-FOXO3a, thereby preventing the degradation of p-FOXO3a by proteasomes [2]. (-) - (S) - Equol may selectively increase the survival of INS-1 cells by activating PKA signaling. (-) - (S) - Equol may be used as an anti type 2 diabetes drug. In INS-1 pancreas β In cells, (-) - (S) - Equol induces phosphorylation of cAMP responsive element binding proteins on Ser133 and induces cAMP responsive element mediated transcription [3].
In vivo studies (-) - (S) - Equol, compared to the control on day 33, showed inhibition of tumor growth by 43.2% and 28.4%, indicating that the compound did not exhibit significant toxicity [2].
Cell experiments inoculate PC3 cells onto a 96 well culture plate (approximately 5 × 103 cells/well) and cultured overnight at 37 ℃. Next, incubate the cells with a culture medium containing a specified concentration of (-) - (S) - Equol and/or DMSO at 37 ℃ for 72 hours. Determine cell viability through MTT assay [2].
Animal experiment mice: Randomly divide the mice into three groups, with six mice in each group, and treat them with intragastric administration. The experimental group was treated with 10mg/kg or 20mg/kg body weight (-) - (S) - Equol (mice were treated for 33 days per day). The control group was treated with the same volume of 0.01ml sesame seed oil and 0.09mL physiological saline. Check the size of the tumor every three days.

Hebei Sankai Chemical Technology Co., Ltd. is a new chemical enterprise integrating the research, manufacturing and supply of chemicals. Located in the beautiful "cattle city" Xingtai, Hebei Sankai Chemical Technology Co., Ltd. is mainly engaged in the research of chemical fertilizer. At the same time, we have made great breakthroughs in food, feed additives, cosmetics, dyes and industrial chemicals. Our company spirit of "integrity management, quality control, customer first" belief, at home and abroad enjoy high reputation.