1. Burgess reagent is easy to oxidize, and at the same time it is also very sensitive to moisture, and should be used immediately after fresh preparation.

2. Burgess reagent is a highly efficient dehydrogenation reagent that can be used for the preparation reaction from formamide, nitroalkane compounds to isocyanide, nitrile and oxide nitrile compounds. In recent years, the biggest use of Burgess reagent is to realize the cyclic dehydrogenation reaction of hydroxyamide and sulfamide to obtain the corresponding heterocyclic compound.

The chiral center attached to 2-C in thiazoline is prone to epimerization, so much so that most cyclic dehydrogenation reactions of hydroxysulfamides produce enantiomer mixtures. However, under the induction of Burgess Reagent 1, hydroxysulfamide will obtain chiral monomers with high stereoselectivity of 96% yield and greater than 94% enantioselectivity.

Compared with Burgess Reagent 2 itself, the reagent 1 obtained by ligating Burgess reagent with polyethylene glycol can induce the preparation of zoline and thiazoline compounds at a higher yield.

Induced by dehydrogenation reagent 2, hydroxysulfamide can be converted to thiazide at high yield, which is a higher yield than the Mitusnobu reaction.

1. Reference value (XlogP) for calculating hydrophobic parameters: 2

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond receptors: 5

4. Number of rotatable chemical bonds: 6

5. Number of tautomers:

6. Topological molecular polar surface area (TPSA): 78.8

7. Number of heavy atoms: 15

8. Surface charge: 0

9. Complexity: 306

10. Number of isotope atoms: 0

11. Determine the number of atomic stereoscopic centers: 0

12. Uncertain number of atomic stereoscopic centers: 0

13. Determine the number of chemical bond stereotactic centers: 1

14. The number of stereotactic centers of uncertain chemical bonds: 0

15. Number of covalent bond units: 1

1. Properties: creamy crystalline powder

2. Density (g/mL, 20°C): not determined

3. Relative vapor density (g/mL, air = 1): not determined

4. Melting point (ºC): 76-79

5. Boiling point (ºC, normal pressure): not determined

6. Boiling point (ºC, KPa): not determined

7. Refractive index: not determined

8. Flash point (ºC): Not determined

9. Specific optical rotation (º): not determined

10. Spontaneous ignition point or ignition temperature (ºC): not determined

11. Vapor pressure (Pa, 20ºC): not determined

12. Saturation vapor pressure (KPa, 25ºC): not determined

13. Heat of combustion (KJ/mol): not determined

14. Critical temperature (ºC): not determined

15. Critical Pressure (KPa): Not determined

16. Logarithmic value of oil-water (octanol/water) partition coefficient: not determined

17. Upper limit of explosion (%, V/V): Not determined

18. Lower explosion limit (%, V/V): not determined

19. Solubility: Not determined